Remove the appropriate indication-specific volume from a port (second injection site) on the infusion line after the infusion set is primed. If the 100 mg vial is used, the needle should be inserted away from the puncture mark made by the transfer device. If this method is used with 50 mg vials, the syringe should not be primed with air and the needle should be inserted into the vial stopper. Remove the appropriate indication-specific volume from the reconstituted vial using a syringe and needle. The bolus dose may be prepared in one of three ways: Following dilution, the solution is stable for up to 8 hours at room temperature. Polyvinyl chloride bags or glass vials are acceptable for dilution. The reconstituted solution may be administered as the 1 mg/mL solution or alternatively, the reconstituted solution may be further diluted with an equal volume of 0.9% Sodium Chloride Injection or 5% Dextrose Injection to a concentration of 0.5 mg/mL. Separate the alteplase vial from the transfer device and gently swirl to dissolve the powder. The concentration of alteplase solution is 1 mg/mL. Invert the two vials so that the vial of alteplase is on the bottom and allow the entire amount of water to flow into the alteplase vials (about 0.5 mL will remain in the Sterile Water for Injection vial). Push the vial down so that the piercing pin is inserted through the center of the vial stopper. Remove the protective cap from a vial of alteplase and hold it upside-down over the piercing pin of the transfer device. Keeping the vial of Sterile Water for Injection upright, insert the piercing pin of the transfer device (provided by the manufacturer) vertically into the center of the stopper. The reconstituted product is a colorless to pale yellow transparent solution.ġ00 mg vials: Vials do not contain vacuum. Slight foaming upon reconstitution may occur standing undisturbed for several minutes is sufficient to allow dissipation of any large bubbles. Be sure to direct the stream of water into the lyophilized cake. Using a large bore needle (e.g., 18 gauge) and a syringe add the Sterile Water for Injection supplied by the manufacturer to the vial containing alteplase to make a solution containing 1 mg/mL. Alteplase is administered intravenously as a bolus injection or infusion.ĥ0 mg vials: Vials contain a vacuum do not use if vacuum is not present.
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